Shandong Freda Biotechnology Co., Ltd., based in Jinan, Shandong Province, China, is a global biotechnology leader specializing in the research, production, and export of natural bioactive ingredients and functional biopolymers. As a wholly owned subsidiary of the Freda Pharmaceutical Group, the company integrates pharmaceutical-grade quality systems into its ingredient manufacturing, serving industries ranging from food preservation and functional nutrition to high-end cosmetics and personal care.
Company Overview
Established with a mission to deliver natural, safe, and effective bio-ingredients through green biotechnology, Freda Biotechnology has grown into one of China’s most influential producers of fermentation-derived compounds. Its operations are vertically integrated, encompassing strain development, fermentation, purification, formulation, and export logistics.
The company exports to over 60 countries and regions and maintains a strong presence in regulated markets such as the United States, European Union, Japan, and South Korea.
Core Product Portfolio
1. Natamycin
- A natural antifungal agent derived from Streptomyces natalensis
- Widely used as a food preservative in cheese, baked goods, cured meats, and beverage applications
- Approved by FDA (GRAS status), EFSA, China GB2760, and Codex Alimentarius
- Available in multiple grades: 50% powder, 95% pure, and water-dispersible formats
- Annual production capacity: over 300 MT
2. Nisin
- Natural bacteriocin produced by Lactococcus lactis
- Inhibits gram-positive bacteria including Listeria, Staphylococcus, and Clostridium
- Used in meat products, dairy, canned food, and condiments
- Compliant with E234 (EU), GRAS (USA), and GB2760 (China) standards
3. Gamma-Aminobutyric Acid (GABA)
- Fermentation-derived non-protein amino acid functioning as a neurotransmitter
- Used in functional beverages, supplements, and sleep-enhancement products
- Also applied in stress relief skincare formulations
- High-purity, food-grade and cosmetic-grade versions available
4. Pullulan
- Water-soluble polysaccharide produced by Aureobasidium pullulans
- GRAS-approved, used in:
- Edible films and coatings
- Oral dissolving strips
- Encapsulation of active ingredients
- Excellent oxygen barrier and adhesive properties
5. Polyglutamic Acid (PGA)
- Biopolymer made through microbial fermentation of Bacillus subtilis
- High water retention, used in:
- Moisturizing skincare products
- Food thickening and stabilizing
- Agriculture as a water-preserving agent
- Available in γ-PGA powder and sodium polyglutamate form
6. Ectoin
- Natural extremolyte produced by halophilic bacteria
- Cellular stress protection ingredient used in high-end cosmetics
- Functions:
- Anti-pollution
- UV protection
- Skin hydration
- Anti-aging
- Exported primarily to premium European and Asian skincare brands
7. Pro-Xylane
- Synthetic xylopyranose derivative used in anti-aging and firming skincare
- Enhances extracellular matrix regeneration
- Frequently formulated in luxury cosmetic serums and emulsions
Manufacturing and Technical Capabilities
Shandong Freda operates GMP-standard production facilities with:
- Fermentation tanks ranging from 5,000L to 20,000L
- In-house downstream purification using column chromatography, filtration, and crystallization
- Freeze-drying, spray-drying, and granulation for powder formats
- Cleanroom-grade packaging for pharmaceutical and cosmetic ingredients
Annual production capacities:
- Natamycin: 300+ MT
- Nisin: 100+ MT
- Pullulan: 1,200 MT
- PGA: 800 MT
- GABA: 600 MT
- Ectoin/Pro-Xylane: Limited batch high-purity production
Certifications and Regulatory Compliance
Freda Biotechnology adheres to the highest standards in food, pharmaceutical, and cosmetic ingredient manufacturing:
- ISO 9001: Quality Management System
- ISO 22000 / HACCP: Food Safety
- GMP Certification (Food & Cosmetic Ingredients)
- Halal & Kosher
- GRAS (USA)
- REACH (EU)
- FDA DMF Filing for certain pharmaceutical excipients
Each product batch is supplied with:
- Certificate of Analysis (COA)
- MSDS and TDS
- Residual solvent and heavy metal reports
- Microbial testing results
Export and Global Trade Insights
Freda Biotechnology maintains a dominant position in export markets for natural preservatives and biotech cosmetic ingredients. Trade and customs data reflect:
- Over 3,800 international shipments recorded between 2019 and 2024
- Major export markets: United States, Germany, Netherlands, Japan, South Korea, India, Brazil
- Key exported products: Natamycin, Pullulan, GABA, Ectoin
- Average shipment value: $25,000 to $85,000 USD, depending on compound and formulation
The company exhibits regularly at global trade shows including Vitafoods Europe, Hi Japan, In-Cosmetics Global, and CPhI Worldwide.
Target Markets and Applications
- Food & Beverage: Antimicrobial preservatives, functional amino acids
- Nutraceuticals: GABA supplements, Pullulan-based capsules
- Pharmaceuticals: Oral film technologies, stabilizers, and biopolymers
- Cosmetics: Ectoin, PGA, and Pro-Xylane in hydration, anti-aging, and barrier protection formulations
- Medical Nutrition and Clinical Food
Competitive Advantages
- Integrated fermentation and chemical synthesis technology platforms
- Deep R&D pipeline with multiple patent families (over 50 patents granted)
- Global regulatory experience with full documentation support for exports
- High-capacity and scalable production to support global OEMs
- Strong brand equity under Freda®, widely recognized in biotech ingredient sourcing
Strategic Collaborations and R&D
Freda partners with:
- Chinese Academy of Sciences
- Qilu University of Technology
- International cosmetic brands and pharmaceutical ingredient developers
Focus areas:
- Biotechnology innovation in postbiotic skincare
- Clean-label food preservation
- Smart biopolymer design for drug delivery and food packaging
Sustainability and Quality Ethics
- Uses non-GMO microbial strains
- Implements closed-loop water and waste systems
- Prioritizes biodegradable and natural alternatives to synthetic preservatives
- Adheres to ethical sourcing and labor practices
Strategic Vision
Shandong Freda Biotechnology aims to expand its leadership in natural functional ingredients by:
- Scaling up postbiotic and microbiome-related skincare actives
- Investing in AI-assisted strain development
- Expanding pullulan applications in pharmaceutical and oral delivery systems
- Enhancing supply chain digitalization to improve global B2B logistics
With its extensive international certifications, high R&D output, and product relevance across industries, Freda Biotechnology continues to shape the future of safe, effective, and sustainable bio-based solutions.
