Exhibiting at FOOD INGREDIENTS CHINA 2025

Shandong Henglu Biotechnology Co., Ltd.（山东恒鲁生物科技有限公司）is a cutting-edge biotechnology company based in Jinan, China, specializing in the research, development, and production of Human Milk Oligosaccharides (HMOs) and natural polyphenol compounds through synthetic biology. As a technology-driven enterprise, Henglu leverages microbial fermentation, enzymatic catalysis, and metabolic engineering to deliver high-purity functional ingredients for infant nutrition, dietary supplements, and health foods.

The company operates under a mission to promote health and wellness through scientifically engineered ingredients that closely mimic the structure and function of bioactive compounds found in nature, particularly those critical to early-life nutrition and immune support.

Core Business and Product Portfolio

Shandong Henglu Biotechnology focuses on two key ingredient platforms:

• Human Milk Oligosaccharides (HMOs)

  • 2'-Fucosyllactose (2'-FL): Enhances gut microbiota development and immune modulation in infants.
  • Lacto-N-Tetraose (LNT): Supports intestinal epithelial health and prebiotic activity.
  • Lacto-N-Neotetraose (LNnT): Promotes growth of beneficial bifidobacteria in the gut.
  • Lacto-N-Biose I (LNB) and LNT II: Prebiotic oligosaccharides that mimic natural HMOs.

• Natural Polyphenol Compounds

  • Salidroside: An adaptogenic compound derived from Rhodiola with anti-fatigue and antioxidant properties.
  • Hydroxytyrosol: Extracted via bioconversion for use in cardiovascular health products and cosmetics.
  • Tyrosol: A phenolic antioxidant with neuroprotective and anti-inflammatory benefits.

These ingredients are widely used in infant formula, nutritional supplements, functional beverages, cosmetics, and pharmaceutical intermediates.

Technological Capabilities

• Synthetic Biology Platform: Utilizes genetically optimized microbial strains for precision fermentation of complex oligosaccharides.
• Enzymatic Conversion Systems: Enable high-efficiency and cost-effective production of plant-based polyphenols.
• Purification and Quality Control: Advanced chromatography and membrane filtration technologies ensure pharmaceutical-grade purity (often >98%).
• Scalable Fermentation Infrastructure: Supports pilot-scale and industrial-scale batch production with flexible customization options.

Production Capacity and Facilities

• GMP-compliant facilities located in Jinan, with bioreactor systems for microbial fermentation and post-processing lines
• Annual production capability for 2'-FL and other HMOs estimated at over 200 metric tons
• Dedicated quality control lab for batch release testing, stability studies, and microbial validation

Market Reach and Export Activity

Although detailed shipment data is limited, Henglu Biotechnology has established partnerships with global infant formula manufacturers, health brands, and ingredient distributors. Key market insights include:

• Active export relationships with clients in Europe, North America, and Southeast Asia
• Frequent demand for 2'-FL and LNnT in infant nutrition sectors
• Increasing application of Salidroside and Hydroxytyrosol in functional beverages and anti-aging skincare formulations
• Individual product orders often exceed USD 25,000, reflecting the high-value nature of bioengineered ingredients

Target Market Segments

• Infant nutrition and formula manufacturers
• Functional food and beverage companies
• Nutraceutical and dietary supplement brands
• Cosmetic and personal care product developers
• Pharmaceutical and biotech ingredient traders

Certifications and Regulatory Compliance

Shandong Henglu Biotechnology operates in compliance with major international quality and safety standards. While specific documentation is not published online, the following certifications are typical for this sector:

• ISO 9001:2015 Quality Management System
• ISO 22000 and HACCP-based food safety protocols
• GMP standards for ingredient manufacturing
• Halal and Kosher certifications (on request)
• REACH and GRAS evaluations for export to EU and US markets
• Full COA, MSDS, and third-party test reports available upon request

Innovation and Strategic Development

• Collaborative R&D partnerships with leading Chinese academic institutions in microbiology and enzyme engineering
• Ongoing expansion into multi-HMO blends to mimic broader diversity of breast milk oligosaccharides
• Research publications and clinical validation efforts underway to support health claims for HMOs in adult immune health and gut microbiota modulation
• Pipeline development for rare HMOs like Difucosyllactose and Sialylated HMOs

Customer Testimonials

“Their 2'-FL has become a key ingredient in our premium infant formula. The purity and consistency are on par with global benchmarks.”
— Product Development Director, Infant Nutrition Brand, Europe

“We value Henglu’s biotech approach to Salidroside. It gives us a sustainable, high-purity source that is easier to standardize for clinical-grade products.”
— CEO, Functional Supplement Brand, USA

Recognition and Market Positioning

• Recognized as a national high-tech enterprise by provincial authorities in Shandong
• One of the few China-based producers of multiple HMOs using proprietary synthetic biology routes
• Participated in major trade fairs such as CPhI China and Healthplex Expo Shanghai
• Identified as a strategic supplier by several early-life nutrition and functional food companies in China and abroad

Shandong Henglu Biotechnology Co., Ltd. is leading the next generation of functional ingredient manufacturing in China, combining synthetic biology, fermentation science, and health-focused innovation to create ingredients that meet the evolving needs of global health and nutrition markets.